|1.||Nat Rev Genet. 2012 Sep 11. doi: 10.1038/nrg3295. [Epub ahead of print]|
Revising the human mutation rate: implications for understanding human evolution.Scally A, Durbin R.
Wellcome Trust Sanger Institute, Hinxton, UK.
It is now possible to make direct measurements of the mutation rate in modern humans using next-generation sequencing. These measurements reveal a value that is approximately half of that previously derived from fossil calibration, and this has implications for our understanding of demographic events in human evolution and other aspects of population genetics. Here, we discuss the implications of a lower-than-expected mutation rate in relation to the timescale of human evolution.
|PMID: 22965354 [PubMed - as supplied by publisher]|
Thursday, 13 September 2012
[pub]: Revising the human mutation rate: implications for understanding human evolution.
Posted by Kevin at 00:02