http://www.nature.com/nature/journal/v463/n7283/full/nature08795.html
Just attended a very good lecture by Stephan Schuster, entitled "African Genomes: Charting Human Diversity"
Just attended a very good lecture by Stephan Schuster, entitled "African Genomes: Charting Human Diversity"
He offered unbiased views / charts on the platform differences between 454, GAIIx, HiSeq, SOLiD for NGS sequencing coverage (which I think I should not repeat here). It points to the need to do sequencing on 2 different platforms to get a more accurate SNP list.
He also gave compelling reasons for getting a 20x coverage of Human genome done in 454 to complete the human genome (457 gaps in hg19).
Yes, I often forget that the media / lay person thinks that the human genome is 'complete'. It's a often ignored 'secret' that actually it isn't. Maybe the next marketing ploy(i mean strategy) for emerging sequencing platforms would be to be THE ONE that actually finishes the human genome.
