|1.||Bioinformatics. 2012 Jul 3. [Epub ahead of print]|
OmegaPlus: A Scalable Tool for Rapid Detection of Selective Sweeps in Whole-Genome Datasets.Alachiotis N, Stamatakis A, Pavlidis P.
The Exelixis Lab, Scientific Computing Group, Heidelberg Institute for Theoretical Studies.
MOTIVATION: Recent advances in sequencing technologies have led to the rapid accumulation of molecular sequence data. Analyzing whole-genome data (as obtained from next-generation sequencers) from intra-species samples allows to detect signatures of positive selection along the genome and therefore identify potentially advantageous genes in the course of the evolution of a population.We introduce OmegaPlus, an open-source tool for rapid detection of selective sweeps in whole-genome data based on linkage dis-equilibrium. The tool is up to two orders of magnitude faster than existing programs for this purpose and also exhibits up to two orders of magnitude smaller memory requirements. AVAILABILITY: OmegaPlus is available under GNU GPL at http://www.exelixis-lab.org/software.html. CONTACT: firstname.lastname@example.org SUPPLEMENTARY INFORMATION: Available at Bioinformatics online.
|PMID: 22760304 [PubMed - as supplied by publisher]|
Friday, 6 July 2012
OmegaPlus: A Scalable Tool for Rapid Detection of Selective Sweeps in Whole-Genome Datasets.
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Posted by Kevin at 22:19