By Monica Heger
When paired with next-gen sequencing technology, OpGen's Argus optical mapping technology can correct errors in assembled genomes and help close gaps, a company official said last week at a presentation during a one-day conference of BGI users in Rockville, Md.
Trevor Wagner, a senior scientist at OpGen, presented data on how the company has used the Argus platform to find errors in microbial assemblies from the Human Microbiome Project, as well as in finished genomes, and to close introduced gaps in sequenced human genomes.
While the platform has mostly been used for smaller genomes like bacteria and microbes, Wagner said that the company is now also moving into mammalian and plant genomes, using a "hybrid approach" that combines next-gen sequencing with single-molecule restriction maps.
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