Friday, 27 May 2011

Sean Grimmond shares his plans for his 5500xl upgrades at the Institute for Molecular Bioscience at the University of Queensland

The 5500xl recently found its home at the Institute for Molecular Bioscience at the University of Queensland and Sean Grimmond shared his thoughts about what this means for the lab:


"The 5500xl is first step towards upgrading the SOLiD fleet at the Queensland Centre for Medical Genomics. We are currently working thorugh establishing new operating procedures for genome sequencing (long mate pair and barcoded Exomes) and transcriptome (barcoded whole transcriptome and small rnas) on the new platform.


Our plan is to make the 5500XL the engine behind all our large scale sequencing efforts at the QCMG. Our flagship project is Australia's pancreatic and ovarian cancer genome and transcriptome sequencing efforts which are part of the international cancer genome consortium. This program is seeing us sequence matched normal and tumor genomes/transcriptomes/methylomes for 500 cancer patients. We are particularly keen to employ exact call chemistry in these cancer genome studies and push the accuracy and sensitivity of mutation calling.  We also keen to broaden our efforts into stem cell transcriptome profiling by rnaseq on the 5500s, thanks to the higher throughputs/run.  Finally, we are also looking to start our first de novo genome sequencing experiments using a combination of The exact call chemistry and Torrent sequencing."


Sean Grimmond's lab certainly has a lot planned.  We are happy to hear they plan to fully take advantage of 5500xl pay-per-lane sequencing!


Check out the celebration and more photos here.

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