One of the bigger concerns for small labs trying to do NGS is the bioinformatics and its a VERY valid concern.
I am very interested to see how bioinformatics will become like in the next few years when NGS becomes cheap enough for small labs with no IT budget
This is also an interesting article on scalable bioinformatics at geospiza
http://www.geospiza.com/finchtalk/2009/06/bloginar-scalable-bioinformatics_11.html
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