Connecting the Dots: Biology At Scale In The Age Of AI (Broad Institute)

Collected the videos in a playlist 

Connecting the Dots: Biology At Scale In The Age Of AI (Broad Institute)

Nov 9, 2024

1,338 views • Nov 9, 2024

SESSION 1 BRIDGING THE GAP: MODELS FOR BIOLOGICAL PREDICTION Chair: Wengong Jin (MIT) Hilary Finucane (Broad) Mehrtash Babadi (Broad) Keynote II: Alex Rives (Broad) For more information visit: https://www.broadinstitute.org

Meet Evo, the DNA-trained AI that creates genomes from scratch

https://www.science.org/content/article/meet-evo-dna-trained-ai-creates-genomes-scratch ChatGPT, the famous artificial intelligence (AI) chatbot, can summarize Moby Dick, write computer code, and serve up a recipe for chicken à la king because it has much of the written information on the internet at its silicon fingertips. What if it could do the same for DNA?

That’s the advance behind a new study published today in Science. Researchers describe an AI model, schooled on billions of lines of genetic sequences, that can deduce how bacterial and viral genomes operate and use that information to design new proteins and even whole microbial genomes. The model, known as Evo, could help scientists probe evolution, investigate diseases, develop new treatments, and potentially answer a host of other biomedical questions.

“This work is extremely significant,” says computational biologist Arvind Ramanathan of Argonne National Laboratory, who wasn’t connected to the study. The tests the authors put Evo through, he says, provide “a great showcase of applications” for the AI.