tag:blogger.com,1999:blog-8959227089815463704.post7781157628558989240..comments2023-10-02T17:00:45.520+08:00Comments on Kevin's GATTACA World: Illumina: an alternative to 454 in metagenomics?Unknownnoreply@blogger.comBlogger1125tag:blogger.com,1999:blog-8959227089815463704.post-90233166709478002222010-05-28T04:22:28.722+08:002010-05-28T04:22:28.722+08:00Most good alignment tools take into account the ma...Most good alignment tools take into account the mate distance (BFAST/BWA/MAQ/etc) and some even implement a "mate-rescue" (BWA). These not only improve the number of reads that map, but more importantly their confidence. The question I would ask is can you overfit in such situations such that you miss translocations and other structural variation?Anonymousnoreply@blogger.com